How Does Exercise, With and Without Diet, Improve Pain and Function in Knee Osteoarthritis? A Secondary Analysis of a Randomized Controlled Trial Exploring Potential Mediators of Effects

BJ Lawford; RS Hinman; F McManus; KE Lamb; T Egerton; C Keating; C Brown; K Oliver; KL Bennell

Journal article

How Does Exercise, With and Without Diet, Improve Pain and Function in Knee Osteoarthritis? A Secondary Analysis of a Randomized Controlled Trial Exploring Potential Mediators of Effects

BJ Lawford, RS Hinman, F McManus, KE Lamb, T Egerton, C Keating, C Brown, K Oliver, KL Bennell

Arthritis Care and Research | WILEY | Published : 2023

DOI: 10.1002/acr.25140

Abstract

Objective: To explore the mediators of effects of two 6-month telehealth-delivered exercise programs, including exercise with and without weight-loss diet, on pain and function improvements in knee osteoarthritis (OA). Methods: Secondary analysis of 345 participants from a 3-arm randomized controlled trial of exercise (Exercise program) and exercise plus diet (Diet + Exercise program) versus information (Control program) was conducted. Outcomes were changes in pain (11-point numeric rating scale) and function (Western Ontario and McMaster Universities Osteoarthritis Index [score range 0–68]) at 12 months. Potential mediators were change at 6 months in attitudes toward self-management, fear o..

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University of Melbourne Researchers

Belinda Lawford Author

Rana Hinman Author

Fiona McManus Author

Karen Lamb Author

Related Projects (2)

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Grants

Awarded by Medibank Better Health Foundation

Funding Acknowledgements

Supported by Medibank, the Medibank Better Health Foundation Research Fund, and the National Health and Medical Research Council Centre of Research Excellence (grant APP-1079078).Dr. Hinman's work was supported by the National Health and Medical Research Council (Fellowship grant 1154217). Dr. Bennell's work was supported by the National Health and Medical Research Council (Investigator grant 1174431).